Pd-Catalyzed C(sp<sup>2</sup>)-H Imidoylative Annulation: A General Approach To Construct Dibenzoox(di)azepines.

Hu, Weiming; Teng, Fan; Hu, Huaanzi; Luo, Shuang; Zhu, Qiang

Pd-Catalyzed C(sp²)-H Imidoylative Annulation: A General Approach To Construct Dibenzoox(di)azepines.

Hu, Weiming; Teng, Fan; Hu, Huaanzi; Luo, Shuang; Zhu, Qiang.

Afiliação

Hu W; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health , Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.
Teng F; University of Chinese Academy of Sciences, No. 19(A) Yuquan Road , Shijingshan District, Beijing 100049 , China.
Hu H; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health , Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.
Luo S; University of Chinese Academy of Sciences, No. 19(A) Yuquan Road , Shijingshan District, Beijing 100049 , China.
Zhu Q; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health , Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

J Org Chem ; 84(10): 6524-6535, 2019 05 17.

Article em En | MEDLINE | ID: mdl-31050283

RESUMO

A general method to construct the scaffolds of dibenzooxazepine and dibenzodiazepine, through Pd-catalyzed isocyanide insertion and intramolecular C(sp2)-H activation, has been developed. This is the first example of seven-membered heterocycle formation by C-H imidoylative annulation.

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China