Elevated oxidized lipids, anti-lipid autoantibodies and oxidized lipid immune complexes in active SLE.
Clin Immunol
; 205: 43-48, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31075396
ABSTRACT
BACKGROUND:
Here, we explore the serum levels of anti-oxidized lipid autoantibodies as well as immune complexes in patients with SLE and determine their correlation with disease.METHODS:
Serum levels of oxidized-LDL immune complexes, autoantibodies to dsDNA, ox-LDL, MDA-LDL, 9-HODE, 13-HODE and POVPC were detected by ELISA in 64 SLE patients and 9 healthy controls.RESULTS:
Active SLE patients exhibited increased serum levels of autoantibodies compared to healthy controls, including anti-MDA-LDL-IgG (pâ¯=â¯.003), anti-ox-LDL-IgG (pâ¯=â¯.004), anti-9-HODE-IgG (pâ¯=â¯.001), anti-13-HODE-IgG (pâ¯=â¯.0003), anti-POVPC-IgG (pâ¯=â¯.001) and ox-LDL-IC (pâ¯=â¯.003). Serum anti-ox-LDL-IgG was positively correlated with SLEDAI (râ¯=â¯0.34; pâ¯=â¯.01), and negatively with C3 (râ¯=â¯-0.40; pâ¯=â¯.01). Anti-9-HODE-IgG and anti-POVPC-IgG were positively correlated with SLEDAI and negatively with C4.CONCLUSIONS:
Active SLE patients exhibit significantly increased serum levels of IgG anti-oxidized-lipid autoantibodies. Coordinated elevation of oxidized lipids, autoantibodies to these lipids, and immune complexes of these lipid-antibody components could potentially serve as pathogenic drivers and serum markers of SLE disease activity.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Clin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China