Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus.

Kanitz, Manuel; Blanck, Sandra; Heine, Andreas; Gulyaeva, Anastasia A; Gorbalenya, Alexander E; Ziebuhr, John; Diederich, Wibke E

Kanitz, Manuel; Blanck, Sandra; Heine, Andreas; Gulyaeva, Anastasia A; Gorbalenya, Alexander E; Ziebuhr, John; Diederich, Wibke E.

Afiliação

Kanitz M; Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany; Institute of Pharmaceutical Chemistry, Philipps University, Marburg, Germany.
Blanck S; Institute of Medical Virology, Justus Liebig University, Giessen, Germany.
Heine A; Institute of Pharmaceutical Chemistry, Philipps University, Marburg, Germany.
Gulyaeva AA; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Gorbalenya AE; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
Ziebuhr J; Institute of Medical Virology, Justus Liebig University, Giessen, Germany. Electronic address: john.ziebuhr@viro.med.uni-giessen.de.
Diederich WE; Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany; Institute of Pharmaceutical Chemistry, Philipps University, Marburg, Germany. Electronic address: wibke.diederich@staff.uni-marburg.de.

Virology ; 533: 21-33, 2019 07.

Article em En | MEDLINE | ID: mdl-31078932

Assuntos

Culicidae/virologia; Cisteína Proteases/química; Cisteína Proteases/metabolismo; Nidovirales/enzimologia; Proteínas Virais/química; Proteínas Virais/metabolismo; Motivos de Aminoácidos; Sequência de Aminoácidos; Animais; Sítios de Ligação; Catálise; Cristalografia por Raios X; Cisteína Proteases/genética; Nidovirales/química; Nidovirales/genética; Alinhamento de Sequência; Especificidade por Substrato; Proteínas Virais/genética

Palavras-chave

3C-like protease; Active site of chymotrypsin-like proteases; Coronavirus; Crystal structure; Invertebrate RNA virus; Mesonivirus

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteínas Virais / Nidovirales / Cisteína Proteases / Culicidae Limite: Animals Idioma: En Revista: Virology Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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