Suppression of Active HIV-1 Infection in CD34<sup>+</sup> Hematopoietic Humanized NSG Mice by a Combination of Combined Antiretroviral Therapy and CCR5 Targeting Drugs.

Latinovic, Olga S; Neal, Lauren M; Tagaya, Yutaka; Heredia, Alonso; Medina-Moreno, Sandra; Zapata, Juan C; Reitz, Marvin; Bryant, Joseph; Redfield, Robert R

Suppression of Active HIV-1 Infection in CD34⁺ Hematopoietic Humanized NSG Mice by a Combination of Combined Antiretroviral Therapy and CCR5 Targeting Drugs.

Latinovic, Olga S; Neal, Lauren M; Tagaya, Yutaka; Heredia, Alonso; Medina-Moreno, Sandra; Zapata, Juan C; Reitz, Marvin; Bryant, Joseph; Redfield, Robert R.

Afiliação

Latinovic OS; 1Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
Neal LM; 2Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland.
Tagaya Y; 1Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
Heredia A; 1Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
Medina-Moreno S; 3School of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Zapata JC; 1Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
Reitz M; 3School of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Bryant J; 1Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.
Redfield RR; 1Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland.

AIDS Res Hum Retroviruses ; 35(8): 718-728, 2019 08.

Article em En | MEDLINE | ID: mdl-31099257

Assuntos

Fármacos Anti-HIV/farmacologia; Infecções por HIV/tratamento farmacológico; HIV-1/efeitos dos fármacos; Transplante de Células-Tronco Hematopoéticas; Receptores CCR5/efeitos dos fármacos; Animais; Antígenos CD34/metabolismo; Relação CD4-CD8; Linfócitos T CD4-Positivos/imunologia; Modelos Animais de Doenças; Células-Tronco Hematopoéticas/virologia; Humanos; Subunidade gama Comum de Receptores de Interleucina/genética; Maraviroc/farmacologia; Camundongos; Camundongos Knockout; Camundongos SCID; Sirolimo/farmacologia; Carga Viral/efeitos dos fármacos; Viremia/tratamento farmacológico

Palavras-chave

HIV-1; HIV-1 persistence; HIV-1 prevention; antiretroviral therapy

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Transplante de Células-Tronco Hematopoéticas / Fármacos Anti-HIV / Receptores CCR5 Limite: Animals / Humans Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2019 Tipo de documento: Article

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