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Synapsins regulate α-synuclein functions.
Atias, Merav; Tevet, Yaara; Sun, Jichao; Stavsky, Alexandra; Tal, Shani; Kahn, Joy; Roy, Subhojit; Gitler, Daniel.
Afiliação
  • Atias M; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
  • Tevet Y; Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
  • Sun J; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
  • Stavsky A; Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
  • Tal S; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705.
  • Kahn J; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
  • Roy S; Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
  • Gitler D; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel.
Proc Natl Acad Sci U S A ; 116(23): 11116-11118, 2019 06 04.
Article em En | MEDLINE | ID: mdl-31110014
ABSTRACT
The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Vesículas Sinápticas / Sinapsinas / Alfa-Sinucleína Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Israel
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Vesículas Sinápticas / Sinapsinas / Alfa-Sinucleína Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Israel