A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL.
Exp Cell Res
; 382(1): 111453, 2019 09 01.
Article
em En
| MEDLINE
| ID: mdl-31158361
ABSTRACT
Long non-coding RNAs (lncRNAs) are reported to play a significant role in various malignant tumors, yet their potential functions in gastric cancer are not clear. In this study, we found a novel lncRNA, named TONSL-AS1, was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803â¯cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo. Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Additionally, the TONSL-AS1 was positively associated with TONSL in cancer tissues. Our study revealed that the tumor-inhibiting effect of TONSL-AS1 in gastric cancer cells was associated with TONSL. In general, our results indicated that TONSL-AS1 works as a tumor suppressor lncRNA, which may be a new therapeutic target for gastric cancer.
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Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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RNA Neoplásico
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Regulação Neoplásica da Expressão Gênica
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Genes Supressores de Tumor
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NF-kappa B
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Proteínas de Neoplasias
Limite:
Adult
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Aged
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Exp Cell Res
Ano de publicação:
2019
Tipo de documento:
Article