A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL.

Wang, Peng; Yang, Xi; Zhao, Liang; Liu, Dongxiao; Liu, Junmao; Ding, Yongbin

Wang, Peng; Yang, Xi; Zhao, Liang; Liu, Dongxiao; Liu, Junmao; Ding, Yongbin.

Afiliação

Wang P; Department of General Surgery, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University. No.1399, Shichang Road, Shengze Town, Suzhou City, Jiangsu, China; Department of General Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. No.1-1, Zhongfu Road, Nanjin
Yang X; Department of Gastroenterology, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University. No. 1399, Shichang Road, Shengze Town, Suzhou City, Jiangsu, China.
Zhao L; Department of General Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. No.1-1, Zhongfu Road, Nanjing, Jiangsu, China.
Liu D; Department of General Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. No.1-1, Zhongfu Road, Nanjing, Jiangsu, China.
Liu J; Department of General Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine. No.1-1, Zhongfu Road, Nanjing, Jiangsu, China.
Ding Y; Department of General Surgery, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University. No.1399, Shichang Road, Shengze Town, Suzhou City, Jiangsu, China; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University. No. 300, Guangzhou Road, Nanjing, Jiang

Exp Cell Res ; 382(1): 111453, 2019 09 01.

Article em En | MEDLINE | ID: mdl-31158361

ABSTRACT

ABSTRACT

Long non-coding RNAs (lncRNAs) are reported to play a significant role in various malignant tumors, yet their potential functions in gastric cancer are not clear. In this study, we found a novel lncRNA, named TONSL-AS1, was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803â¯cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo. Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Additionally, the TONSL-AS1 was positively associated with TONSL in cancer tissues. Our study revealed that the tumor-inhibiting effect of TONSL-AS1 in gastric cancer cells was associated with TONSL. In general, our results indicated that TONSL-AS1 works as a tumor suppressor lncRNA, which may be a new therapeutic target for gastric cancer.

Assuntos

Regulação Neoplásica da Expressão Gênica/genética; Genes Supressores de Tumor; NF-kappa B/fisiologia; Proteínas de Neoplasias/fisiologia; RNA Neoplásico/fisiologia; Neoplasias Gástricas/genética; Adulto; Idoso; Animais; Carcinogênese; Adesão Celular; Divisão Celular; Linhagem Celular Tumoral; Movimento Celular; Progressão da Doença; Regulação para Baixo; Feminino; Genes Reporter; Humanos; Masculino; Camundongos Endogâmicos BALB C; Camundongos Nus; Pessoa de Meia-Idade; NF-kappa B/genética; Proteínas de Neoplasias/genética; Interferência de RNA; RNA Neoplásico/genética; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/farmacologia; Organismos Livres de Patógenos Específicos

Palavras-chave

Gastric cancer; Long non-coding RNA; TONSL; TONSL-AS1

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Gástricas / RNA Neoplásico / Regulação Neoplásica da Expressão Gênica / Genes Supressores de Tumor / NF-kappa B / Proteínas de Neoplasias Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Exp Cell Res Ano de publicação: 2019 Tipo de documento: Article

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