Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters.
Physiology (Bethesda)
; 34(4): 240-249, 2019 07 01.
Article
em En
| MEDLINE
| ID: mdl-31165682
ABSTRACT
Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to ß-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Proteínas Quinases Dependentes de AMP Cíclico
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AMP Cíclico
Limite:
Animals
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Humans
Idioma:
En
Revista:
Physiology (Bethesda)
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article