The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis.

Zhu, Ruilou; Wang, Jiangnan; Feng, Tianxiang; Hu, Xuechun; Jiang, Chen; Wang, Xiuxing; Li, Kang; Sang, Yongjuan; Hua, Yue; Sun, Haixiang; Yao, Bing; Li, Chaojun

Zhu, Ruilou; Wang, Jiangnan; Feng, Tianxiang; Hu, Xuechun; Jiang, Chen; Wang, Xiuxing; Li, Kang; Sang, Yongjuan; Hua, Yue; Sun, Haixiang; Yao, Bing; Li, Chaojun.

Afiliação

Zhu R; MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and Jiangsu Key Laboratory of Molecular Medicine cell biology, the Medical School of Nanjing University, Nanjing, China.
Wang J; Collaborative Innovation Platform for Reproductive Biology and Technology of the Medical School of Nanjing University, Nanjing, China.
Feng T; MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and Jiangsu Key Laboratory of Molecular Medicine cell biology, the Medical School of Nanjing University, Nanjing, China.
Hu X; MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and Jiangsu Key Laboratory of Molecular Medicine cell biology, the Medical School of Nanjing University, Nanjing, China.
Jiang C; Collaborative Innovation Platform for Reproductive Biology and Technology of the Medical School of Nanjing University, Nanjing, China.
Wang X; Center of Reproductive Medicine, Nanjing Jinling Hospital, the Medical School of Nanjing University, Nanjing, China.
Li K; MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and Jiangsu Key Laboratory of Molecular Medicine cell biology, the Medical School of Nanjing University, Nanjing, China.
Sang Y; MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and Jiangsu Key Laboratory of Molecular Medicine cell biology, the Medical School of Nanjing University, Nanjing, China.
Hua Y; MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and Jiangsu Key Laboratory of Molecular Medicine cell biology, the Medical School of Nanjing University, Nanjing, China.
Sun H; Collaborative Innovation Platform for Reproductive Biology and Technology of the Medical School of Nanjing University, Nanjing, China.
Yao B; MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and Jiangsu Key Laboratory of Molecular Medicine cell biology, the Medical School of Nanjing University, Nanjing, China.
Li C; Collaborative Innovation Platform for Reproductive Biology and Technology of the Medical School of Nanjing University, Nanjing, China.

Cell Death Dis ; 10(6): 450, 2019 06 06.

Article em En | MEDLINE | ID: mdl-31171774

Assuntos

Azoospermia/metabolismo; Barreira Hematotesticular/metabolismo; Farnesiltranstransferase/metabolismo; Complexos Multienzimáticos/metabolismo; Prenilação de Proteína; Espermatogênese/genética; Proteínas ras/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo; Animais; Azoospermia/enzimologia; Berberina/farmacologia; Barreira Hematotesticular/efeitos dos fármacos; Células Cultivadas; Farnesiltranstransferase/genética; Células Germinativas/metabolismo; Humanos; Masculino; Camundongos; Camundongos Knockout; Camundongos Transgênicos; Complexos Multienzimáticos/genética; Células de Sertoli/enzimologia; Células de Sertoli/metabolismo; Espermatócitos/metabolismo; Espermatogênese/efeitos dos fármacos; Testículo/metabolismo; Junções Íntimas/genética; Proteínas ras/química; Proteínas ras/genética; Proteína rhoA de Ligação ao GTP/química; Proteína rhoA de Ligação ao GTP/genética

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Espermatogênese / Barreira Hematotesticular / Prenilação de Proteína / Proteínas ras / Proteína rhoA de Ligação ao GTP / Farnesiltranstransferase / Azoospermia / Complexos Multienzimáticos Limite: Animals / Humans / Male Idioma: En Revista: Cell Death Dis Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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