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Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases.
Ippen, Franziska Maria; Grosch, Julia Katharina; Subramanian, Megha; Kuter, Benjamin Macfarlane; Liederer, Bianca M; Plise, Emile G; Mora, Joana Liliana; Nayyar, Naema; Schmidt, Stephen Paul; Giobbie-Hurder, Anita; Martinez-Lage, Maria; Carter, Scott L; Cahill, Daniel P; Wakimoto, Hiroaki; Brastianos, Priscilla Kaliopi.
Afiliação
  • Ippen FM; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Grosch JK; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Subramanian M; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Kuter BM; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Liederer BM; Genentech, Inc, Drug Metabolism and Pharmacokinetics, South San Francisco, California, USA.
  • Plise EG; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Mora JL; Genentech, Inc, Drug Metabolism and Pharmacokinetics, South San Francisco, California, USA.
  • Nayyar N; Genentech, Inc, Drug Metabolism and Pharmacokinetics, South San Francisco, California, USA.
  • Schmidt SP; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Giobbie-Hurder A; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Martinez-Lage M; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Carter SL; Division of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Cahill DP; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Wakimoto H; Joint Center for Cancer Precision Medicine, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Brastianos PK; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Neuro Oncol ; 21(11): 1401-1411, 2019 11 04.
Article em En | MEDLINE | ID: mdl-31173106
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piperazinas / Pirimidinas / Neoplasias Encefálicas / Neoplasias da Mama / Fosfatidilinositol 3-Quinases / Classe I de Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR Limite: Animals / Female / Humans Idioma: En Revista: Neuro Oncol Assunto da revista: NEOPLASIAS / NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piperazinas / Pirimidinas / Neoplasias Encefálicas / Neoplasias da Mama / Fosfatidilinositol 3-Quinases / Classe I de Fosfatidilinositol 3-Quinases / Serina-Treonina Quinases TOR Limite: Animals / Female / Humans Idioma: En Revista: Neuro Oncol Assunto da revista: NEOPLASIAS / NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos