Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model.
Cell Host Microbe
; 25(6): 803-814.e5, 2019 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-31175044
ABSTRACT
The human gut microbiome is comprised of densely colonizing microorganisms including bacteriophages, which are in dynamic interaction with each other and the mammalian host. To address how bacteriophages impact bacterial communities in the gut, we investigated the dynamic effects of phages on a model microbiome. Gnotobiotic mice were colonized with defined human gut commensal bacteria and subjected to predation by cognate lytic phages. We found that phage predation not only directly impacts susceptible bacteria but also leads to cascading effects on other bacterial species via interbacterial interactions. Metabolomic profiling revealed that shifts in the microbiome caused by phage predation have a direct consequence on the gut metabolome. Our work provides insight into the ecological importance of phages as modulators of bacterial colonization, and it additionally suggests the potential impact of gut phages on the mammalian host with implications for their therapeutic use to precisely modulate the microbiome.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bacteriólise
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Bacteriófagos
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Metaboloma
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Fezes
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Microbioma Gastrointestinal
Limite:
Animals
Idioma:
En
Revista:
Cell Host Microbe
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos