Neonatal hemochromatosis in a newborn with Down syndrome.
Fetal Pediatr Pathol
; 39(1): 62-70, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-31215296
ABSTRACT
Background:
Neonatal hemochromatosis (NH) is a cause of neonatal/pediatric acute liver failure. Liver dysfunction/failure in Down syndrome had been described in relation to increased susceptibility to infection and transient myeloproliferative disease (TMD). The occurrence of NH in Down syndrome is described in only a few case reports. Material andmethods:
A complete autopsy have been performed in a 79-day-old infant with severe liver dysfunction. TMD was suspected antemortem following a report of peripheral blood leukocytosis with 14% atypical cells.Results:
The complete autopsy revealed NH-phenotype to be the cause of liver dysfunction and subsequent death.Conclusion:
Though TMD is a common cause of liver dysfunction in Down syndrome, NH should also be considered in its differential.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Falência Hepática
/
Síndrome de Down
/
Hemocromatose
/
Reação Leucemoide
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Fetal Pediatr Pathol
Assunto da revista:
PATOLOGIA
/
PEDIATRIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Índia