Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse.

Jha, Jay C; Dai, Aozhi; Holterman, Chet E; Cooper, Mark E; Touyz, Rhian M; Kennedy, Chris R; Jandeleit-Dahm, Karin A M

Jha, Jay C; Dai, Aozhi; Holterman, Chet E; Cooper, Mark E; Touyz, Rhian M; Kennedy, Chris R; Jandeleit-Dahm, Karin A M.

Afiliação

Jha JC; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Level 5, Melbourne, VIC, 3004, Australia.
Dai A; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Level 5, Melbourne, VIC, 3004, Australia.
Holterman CE; Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Cooper ME; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Level 5, Melbourne, VIC, 3004, Australia.
Touyz RM; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Kennedy CR; Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Jandeleit-Dahm KAM; Department of Diabetes, Central Clinical School, Monash University, 99 Commercial Road, Level 5, Melbourne, VIC, 3004, Australia. karin.jandeleit-dahm@monash.edu.

Diabetologia ; 62(9): 1712-1726, 2019 09.

Article em En | MEDLINE | ID: mdl-31222503

Assuntos

Albuminúria/metabolismo; Fibrose/metabolismo; Inflamação/metabolismo; Rim/metabolismo; Albuminúria/patologia; Animais; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Nefropatias Diabéticas/metabolismo; Modelos Animais de Doenças; Fibrose/patologia; Humanos; Inflamação/patologia; Rim/patologia; Camundongos; Camundongos Transgênicos; Músculo Liso Vascular/metabolismo; NADPH Oxidase 5/metabolismo; Estresse Oxidativo/fisiologia; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Akita mouse; Albuminuria; Diabetic kidney disease; Endothelial cells; Glomerulosclerosis; VSMCs/mesangial cells

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fibrose / Albuminúria / Inflamação / Rim Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Diabetologia Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália

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