Mechanistic relationship between biodegradation and bioaccumulation. Practical outcomes.
Regul Toxicol Pharmacol
; 107: 104411, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31226393
ABSTRACT
According to the REACH Regulation, for all substances manufactured or imported in amounts of 10 or more tons per year, that are not exempted from the registration requirement, a Chemical Safety Assessment (CSA) must be conducted. According to CSA criteria, for these substances persistent, bioaccumulative and toxic (PBT), and very persistent and very bioaccumulative (vPvB) assessment is requested. In order to reduce the number of applications of the expensive bioaccumulation test it seems useful to search thresholds for other related parameters above which no bioaccumulation is observed. Given the known relationship between ready biodegradability and bioaccumulation, one such parameter is biodegradation. This article addresses this relationship in searching for BOD threshold above which no vB and B chemicals could be observed. It was found that the regulatory criteria for persistency could be used for identification of not vB and B chemicals. In addition, fish liver metabolism is determined as the most significant factor in reducing of maximum bioaccumulation potential of the chemicals. It was found that parameters associated with the models simulating fish metabolism could be also used for identification of not vB and B chemicals.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Peixes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Regul Toxicol Pharmacol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Bulgária