A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain.
Arch Virol
; 164(9): 2355-2358, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31227892
ABSTRACT
Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activity of antiserum against a former vaccine strain. To confirm this suggestion, here, we generated viruses by reverse genetics. Antibody titers against the mutated viruses were one-tenth to one-sixteenth of those against the former vaccine strain. Our findings confirm that this single amino acid substitution reduces the cross-reactivity of antiserum against this former Japanese vaccine.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Vacinas contra Influenza
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Infecções por Orthomyxoviridae
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Glicoproteínas de Hemaglutininação de Vírus da Influenza
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Doenças dos Cavalos
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Anticorpos Antivirais
Limite:
Animals
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão