Current treatment of optic nerve gliomas.
Curr Opin Ophthalmol
; 30(5): 356-363, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-31246635
ABSTRACT
PURPOSE OF REVIEW Optic pathway gliomas are low-grade neoplasms that affect the precortical visual pathway of children and adolescents. They can affect the optic nerve, optic chiasm, optic tracts and radiations and can either be sporadic or associated with neurofibromatosis type one. Gliomas isolated to the optic nerve (ONG) represent a subgroup of optic pathway gliomas, and their treatment remains controversial. New developments in ONG treatment have emerged in recent years, and it is necessary for clinicians to have a current understanding of available therapies. RECENT FINDINGS:
The current review of the literature covers the background of and recent developments in ONG treatment, with a focus on standard chemotherapy, new molecularly targeted therapies, radiation therapy and surgical resection and debulking.SUMMARY:
Although standard chemotherapy remains the mainstay of ONG treatment, newer molecularly targeted therapies such as mitogen-activated protein kinase kinase inhibitors and bevacizumab represent a promising new treatment modality, and clinical studies are ongoing.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Quiasma Óptico
/
Neoplasias do Nervo Óptico
/
Glioma do Nervo Óptico
/
Trato Óptico
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Curr Opin Ophthalmol
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article