General Approach To Construct Azepino[2,3-b:4,5-b']diindoles, Azocino[2,3-b:4,5-b']diindoles, and Azonino[2,3-b:4,5-b']diindoles via Rh(II)-Catalyzed Reactions of 3-Diazoindolin-2-imines with 3-(Bromoalkyl)indoles.

Sheng, Guorong; Li, Zhenmin; Mao, Jianming; Lu, Ping; Wang, Yanguang

Sheng, Guorong; Li, Zhenmin; Mao, Jianming; Lu, Ping; Wang, Yanguang.

Afiliação

Sheng G; Department of Chemistry , Zhejiang University , Hangzhou 310027 , P. R. China.
Li Z; Department of Chemistry , Zhejiang University , Hangzhou 310027 , P. R. China.
Mao J; Department of Chemistry , Zhejiang University , Hangzhou 310027 , P. R. China.
Lu P; Department of Chemistry , Zhejiang University , Hangzhou 310027 , P. R. China.
Wang Y; Department of Chemistry , Zhejiang University , Hangzhou 310027 , P. R. China.

J Org Chem ; 84(15): 9561-9569, 2019 08 02.

Article em En | MEDLINE | ID: mdl-31257884

ABSTRACT

ABSTRACT

Rh(II)-catalyzed reactions of 3-diazoindolin-2-imines with 3-(2-bromoethyl)indoles, 3-(3-bromopropyl)indoles, and 3-(4-bromobutyl)indoles, followed by treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in a one-pot operation furnished azepino[2,3-b4,5-b']diindoles, azocino[2,3-b4,5-b']diindoles, and azonino[2,3-b4,5-b']diindoles, respectively. Structural uniqueness of the products, broad substrate scope, mild reaction conditions, and readily available starting materials are the merits of this approach.

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2019 Tipo de documento: Article