Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.
Nat Metab
; 1(5): 519-531, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-31276102
ABSTRACT
Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The Nrf2 transcription factor orchestrates cell-intrinsic protective antioxidant responses, and the peptide hormone hepcidin maintains systemic iron homeostasis, but is pathophysiologically decreased in haemochromatosis and beta-thalassaemia. Here, we show that Nrf2 is activated by iron-induced, mitochondria-derived pro-oxidants and drives Bmp6 expression in liver sinusoid endothelial cells, which in turn increases hepcidin synthesis by neighbouring hepatocytes. In Nrf2 knockout mice, the Bmp6-hepcidin response to oral and parenteral iron is impaired and iron accumulation and hepatic damage are increased. Pharmacological activation of Nrf2 stimulates the Bmp6-hepcidin axis, improving iron homeostasis in haemochromatosis and counteracting the inhibition of Bmp6 by erythroferrone in beta-thalassaemia. We propose that Nrf2 links cellular sensing of excess toxic iron to control of systemic iron homeostasis and antioxidant responses, and may be a therapeutic target for iron-associated disorders.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Talassemia beta
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Fator 2 Relacionado a NF-E2
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Proteína Morfogenética Óssea 6
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Hepcidinas
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Homeostase
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Ferro
Limite:
Humans
Idioma:
En
Revista:
Nat Metab
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Reino Unido