Regional abnormalities on cardiac magnetic resonance imaging and arrhythmic events in patients with cardiac sarcoidosis.
J Cardiovasc Electrophysiol
; 30(10): 1967-1976, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31328324
ABSTRACT
BACKGROUND:
Patients with cardiac sarcoidosis (CS) may present with arrhythmic events (AE) atrioventricular block (AVB) and/ or ventricular arrhythmias (VA). We sought to (a) use regional analysis of cardiac magnetic resonance imaging (CMR) to describe anatomic and functional phenotypes of patients with CS and AE; (b) Assess the association of regional CMR abnormalities with the combined endpoint of death, heart transplantation (HT) and AE; and (c) use machine learning (ML) to predict the combined endpoint based on CMR features.METHODS:
we included 76 patients with CS and CMR. We analyzed cine images to determine regional longitudinal (LS) and radial strain (RS); and late gadolinium enhancement imaging to determine regional scar burden (%scar).RESULTS:
Patients with AVB (n = 7), compared with those without, had higher %scar in the anterior (21.8 ± 27.4 vs 5.1 ± 8.9; P = 0.0005) and anteroseptal (19.3 ± 24.5 vs 3.5 ± 5.5; P < .0001) walls. Patients with VA (n = 12), compared with those without, had higher %scar in the basal inferoseptum (20.4 ± 30.8 vs 8.3 ± 13.4; P = .03). During mean follow-up of 4.4 ± 3.3 years, four patients died or underwent HT; eight had VA; and zero developed AVB. Multiple regional abnormalities were associated with the combined endpoint, including scar in the anteroseptal wall (HR 1.06 [1.02-1.09] per 1%scar increase, P = .002). The ML algorithm predicted the combined endpoint with a C-statistic of 0.91.CONCLUSION:
Regional CMR abnormalities are associated with AE in patients with CS.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sarcoidose
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Fibrilação Ventricular
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Função Ventricular Esquerda
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Morte Súbita Cardíaca
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Taquicardia Ventricular
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Imagem Cinética por Ressonância Magnética
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Bloqueio Atrioventricular
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Cardiomiopatias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Cardiovasc Electrophysiol
Assunto da revista:
ANGIOLOGIA
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CARDIOLOGIA
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FISIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article