Do Acetylcholinesterase Inhibitors Prevent or Delay Psychotropic Prescribing in People With Dementia? Analyses of the Swedish Dementia Registry.
Am J Geriatr Psychiatry
; 28(1): 108-117, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31331724
ABSTRACT
OBJECTIVES:
To investigate whether acetylcholinesterase inhibitor (AChEI) use prevents or delays subsequent initiation of psychotropic medications in people with Alzheimer's disease (AD) and Lewy body dementia (LBD).METHODS:
Cohort study of 17,763 people with AD and LBD, without prior psychotropic use at time of dementia diagnosis, registered in the Swedish Dementia Registry from 2007 to 2015. Propensity score-matched regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between time-dependent AChEI use and risk of psychotropic initiation.RESULTS:
Compared with matched comparators, AChEI users had a lower risk of antipsychotic (HR 0.85, 95%CI 0.75-0.95) and anxiolytic (HR 0.76, 95%CI 0.72-0.80) initiation. In subanalyses, this association remained significant at higher AChEI doses, and in AD but not LBD. There were no associations between AChEI use and initiation of antidepressants or hypnotics.CONCLUSION:
AChEI use may be associated with lower risk of antipsychotic and anxiolytic initiation in AD, particularly at higher doses. Further investigation into aceytylcholinesterase inhibitors in behavioral and psychological symptoms of dementia management in LBD is warranted.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Prescrições de Medicamentos
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Antipsicóticos
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Ansiolíticos
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Sintomas Comportamentais
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Sistema de Registros
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Inibidores da Colinesterase
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Demência
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Am J Geriatr Psychiatry
Assunto da revista:
GERIATRIA
/
PSIQUIATRIA
Ano de publicação:
2020
Tipo de documento:
Article