Use of advanced heart failure therapies in Duchenne muscular dystrophy.
Prog Pediatr Cardiol
; 53: 11-14, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31360053
ABSTRACT
BACKGROUND:
As survival and neuromuscular function in Duchenne Muscular Dystrophy (DMD) improve with glucocorticoid therapy and respiratory advances, the proportion of cardiac deaths is increasing. Little is known about the use and outcomes of advanced heart failure (HF) therapies in this population.METHODS:
A retrospective cohort study of 436 males with DMD was performed, from January 1, 2005-January 1, 2018, with the primary outcome being use of advanced HF therapies including implantable cardioverter defibrillator (ICD), left ventricular assist device (LVAD), and heart transplantation (HTX).RESULTS:
Nine subjects had an ICD placed, 2 of whom (22.2%) had appropriate shocks for ventricular tachycardia; 1 and 968 days after implant, and all of whom were alive at last follow-up; median 18 (IQR 12.5-25.5) months from implant. Four subjects had a LVAD implanted with post-LVAD survival of 75% at 1 year; 2 remaining on support and 1 undergoing HTX. One subject was bridged to HTX with ICD and LVAD and was alive at last follow-up, 53 months after HTX.CONCLUSION:
Advanced HF therapies may be used effectively in select subjects with DMD. Further studies are needed to better understand risk stratification for ICD use and optimal candidacy for LVAD implantation and HTX, with hopes of improving cardiac outcomes.
Texto completo:
1
Bases de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Prog Pediatr Cardiol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos