Improvement of biosensor accuracy using an interference index detection system to minimize the interference effects caused by icterus and hemolysis in blood samples.
Analyst
; 144(17): 5223-5231, 2019 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-31360940
ABSTRACT
Reagent sensors in diagnostic assays are used in medical laboratories to obtain patient results. However, interference during the analysis of blood samples is a constant problem with reagent sensors and leads to inaccurate results. Interference in blood analysis is frequently caused by hemolysis and icterus. This study analyzed the effects of interferents on reagent sensors and devised a method to improve the measurement accuracy using an interference index detection (IID) system to minimize the interference effect. The IID system can be easily applied using only two wells and an optical component for sample measurement. After applying the IID system, the interference rates from bilirubin and hemoglobin improved dramatically. A comparison of results obtained for clinical samples showed that the IID system had a positive effect on the accuracy.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Análise Química do Sangue
/
Técnicas Biossensoriais
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Confiabilidade dos Dados
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Hemólise
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Icterícia
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Analyst
Ano de publicação:
2019
Tipo de documento:
Article