Propofol Formulation Affects Myocardial Function in Newborn Infants.
Pediatr Cardiol
; 40(7): 1536-1542, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31414158
ABSTRACT
This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups those who received undiluted 1% propofol (P1%); and those who received a diluted formulation (Pd) of equal volumes propofol 1% and 0.9% NaCl. Echocardiograms were performed pre (t0)-, immediately post (t1)-, and 1-h post (t2) propofol administration. Myocardial deformation was assessed with tissue Doppler imaging (TDI) analysis and peak longitudinal strain (LS). 18 cases were included nine (50%) P1% and nine (50%) Pd. In the P1% group, TDI velocities and LS were significantly reduced at t1 and t2. In the Pd Group, only TDI velocities in the left ventricle were reduced at t1, but not at t2. Dilution of propofol may minimize myocardial dysfunction while maintaining adequate sedation in infants. Further comparative studies are needed to investigate the safety and efficacy of this approach.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Propofol
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Hipnóticos e Sedativos
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Contração Miocárdica
Limite:
Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Pediatr Cardiol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália