A model for visual naming based on spatiotemporal dynamics of ECoG high-gamma modulation.
Epilepsy Behav
; 99: 106455, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31419636
ABSTRACT
OBJECTIVE:
We studied spatiotemporal dynamics of electrocorticographic (ECoG) high-gamma modulation (HGM) during visual naming.METHODS:
In 8 patients, aged 4-19â¯years, with left hemisphere subdural electrodes, propagation of ECoG HGM during overt visual naming was mapped with trial-averaged time-frequency analysis. Group-level synthesis was performed by transforming all electrodes to a standard space and assigning cortical parcels based on a reference atlas.RESULTS:
After image display following cortical parcels were activated inferior occipital, caudal angular, fusiform, and middle temporal gyri, and superior temporal sulcus [0-400â¯ms]; rostral pars triangularis (A45r), inferior frontal sulcus, caudal dorsolateral premotor cortex (A6cdl) [300-600â¯ms]; caudal ventrolateral premotor cortex (A6cvl), caudal pars triangularis (A45c), pars opercularis (A44) [400-800â¯ms]; primary sensorimotor cortex [600-1400â¯ms], with most prominent HGM in glossolaryngeal region (A4tl). Lastly, auditory cortex (A41/A42) and superior temporal gyrus (A22) were activated [900â¯ms-1.4â¯s]. After 1.5â¯s, HGM decreased globally, except in ventrolateral premotor cortex.CONCLUSIONS:
During visual naming, ECoG HGM shows a sequential but overlapping spatiotemporal course through cortical regions. We provide neurophysiologic validation for a model of visual naming incorporating both modular and distributed cortical processing. This may explain cognitive deficits seen in some patients after surgery involving HGM naming sites outside perisylvian language cortex.Palavras-chave
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Bases de dados:
MEDLINE
Assunto principal:
Percepção Visual
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Mapeamento Encefálico
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Córtex Cerebral
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Epilepsia Resistente a Medicamentos
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Eletrocorticografia
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Idioma
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Modelos Neurológicos
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Epilepsy Behav
Assunto da revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article