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E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
Burdova, Kamila; Yang, Hongbin; Faedda, Roberta; Hume, Samuel; Chauhan, Jagat; Ebner, Daniel; Kessler, Benedikt M; Vendrell, Iolanda; Drewry, David H; Wells, Carrow I; Hatch, Stephanie B; Dianov, Grigory L; Buffa, Francesca M; D'Angiolella, Vincenzo.
Afiliação
  • Burdova K; Department of Oncology, Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK.
  • Yang H; Department of Oncology, Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK.
  • Faedda R; Department of Oncology, Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK.
  • Hume S; Department of Oncology, Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK.
  • Chauhan J; Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Headington, Oxford, UK.
  • Ebner D; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.
  • Kessler BM; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.
  • Vendrell I; Department of Oncology, Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK.
  • Drewry DH; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.
  • Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Hatch SB; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Dianov GL; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.
  • Buffa FM; Department of Oncology, Medical Research Council Institute for Radiation Oncology, University of Oxford, Oxford, UK.
  • D'Angiolella V; Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russian Federation.
EMBO J ; 38(20): e101443, 2019 10 15.
Article em En | MEDLINE | ID: mdl-31424118
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ciclinas / Proteínas Ligases SKP Culina F-Box / Inibidores de Proteínas Quinases / Fator de Transcrição E2F1 / Proteólise / Quinase 1 do Ponto de Checagem / Mutações Sintéticas Letais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: EMBO J Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ciclinas / Proteínas Ligases SKP Culina F-Box / Inibidores de Proteínas Quinases / Fator de Transcrição E2F1 / Proteólise / Quinase 1 do Ponto de Checagem / Mutações Sintéticas Letais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: EMBO J Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido