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Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models.
Peng, Xia; Hou, Pengcong; Chen, Yi; Dai, Yang; Ji, Yinchun; Shen, Yanyan; Su, Yi; Liu, Bo; Wang, Yueliang; Sun, Deqiao; Jiang, Yuchen; Zha, Chuantao; Xie, Zuoquan; Ding, Jian; Geng, Meiyu; Ai, Jing.
Afiliação
  • Peng X; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Hou P; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
  • Chen Y; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Dai Y; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
  • Ji Y; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Shen Y; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
  • Su Y; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Liu B; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
  • Wang Y; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Sun D; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
  • Jiang Y; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Zha C; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
  • Xie Z; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Ding J; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
  • Geng M; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, No. 555 Zuchongzhi Road, Pudong New District, Shanghai, 201203, People's Republic of China.
  • Ai J; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 100049, People's Republic of China.
J Exp Clin Cancer Res ; 38(1): 372, 2019 Aug 22.
Article em En | MEDLINE | ID: mdl-31438996
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piperazinas / Receptor de Fator Estimulador de Colônias de Macrófagos / Inibidores de Proteínas Quinases / Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Receptor Tipo 2 de Fator de Crescimento de Fibroblastos / Receptor Tipo 3 de Fator de Crescimento de Fibroblastos / Macrófagos / Neoplasias Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Piperazinas / Receptor de Fator Estimulador de Colônias de Macrófagos / Inibidores de Proteínas Quinases / Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Receptor Tipo 2 de Fator de Crescimento de Fibroblastos / Receptor Tipo 3 de Fator de Crescimento de Fibroblastos / Macrófagos / Neoplasias Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2019 Tipo de documento: Article