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CD33 splice site genotype was not associated with outcomes of patients receiving the anti-CD33 drug conjugate SGN-CD33A.
Stanchina, Michele; Pastore, Alessandro; Devlin, Sean; Famulare, Christopher; Stein, Eytan; Taylor, Justin.
Afiliação
  • Stanchina M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Pastore A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Devlin S; Department of Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Famulare C; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Stein E; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • Taylor J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. taylorj7@mskcc.org.
J Hematol Oncol ; 12(1): 85, 2019 08 22.
Article em En | MEDLINE | ID: mdl-31439003
ABSTRACT
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conjugate SGN-CD33A. This genotype, for the CD33 splice site SNP rs12459419, was not associated with clinical response (30% CR/CRi in both groups), event-free survival, or overall survival.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Anticorpos Monoclonais Humanizados / Lectina 3 Semelhante a Ig de Ligação ao Ácido Siálico / Antineoplásicos Imunológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Anticorpos Monoclonais Humanizados / Lectina 3 Semelhante a Ig de Ligação ao Ácido Siálico / Antineoplásicos Imunológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos