Effect of beta2 -adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men.
Scand J Med Sci Sports
; 29(12): 1881-1891, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31442335
ABSTRACT
While beta2 -adrenoceptor stimulation has been shown to increase lean mass and to alter metabolic properties of skeletal muscle, adaptations in muscle oxidative enzymes and maximal oxygen uptake ( V Ë O2max ) in response to beta2 -adrenergic agonist treatment are inadequately explored in humans, particularly in association with resistance training. Herein, we investigated beta2 -adrenergic-induced changes in V Ë O2max , leg and arm composition, and muscle content of oxidative enzymes in response to treatment with the selective beta2 -adrenergic agonist terbutaline with and without concurrent resistance training in young men. Forty-six subjects were randomized to 4 weeks of lifestyle maintenance (n = 23) or resistance training (n = 23). Within the lifestyle maintenance and resistance training group, subjects received daily terbutaline (8 × 0.5 mg) (n = 13) or placebo (n = 10) treatment. No apparent treatment by training interactions was observed during the study period. Terbutaline increased leg and arm lean mass with the intervention, whereas no treatment differences were observed in absolute V Ë O2max and incremental peak power output (iPPO). Treatment main effects were observed for V Ë O2 -reserve (P < .05), V Ë O2max relative to body mass (P < .05), V Ë O2max relative to leg lean mass (P < .01), and iPPO relative to leg lean mass, in which terbutaline had a negative effect compared with placebo. Furthermore, content of electron transport chain complex I-V decreased by 11% (P < .05) for terbutaline compared with placebo. Accordingly, chronic treatment with the selective beta2 -adrenergic agonist terbutaline may negatively affect V Ë O2max and iPPO in relative terms, but not in absolute.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
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Terbutalina
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Músculo Esquelético
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Treinamento Resistido
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Scand J Med Sci Sports
Assunto da revista:
MEDICINA ESPORTIVA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Dinamarca