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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.
Oberlick, Elaine M; Rees, Matthew G; Seashore-Ludlow, Brinton; Vazquez, Francisca; Nelson, Geoffrey M; Dharia, Neekesh V; Weir, Barbara A; Tsherniak, Aviad; Ghandi, Mahmoud; Krill-Burger, John M; Meyers, Robin M; Wang, Xiaofeng; Montgomery, Phil; Root, David E; Bieber, Jake M; Radko, Sandi; Cheah, Jaime H; Hon, C Suk-Yee; Shamji, Alykhan F; Clemons, Paul A; Park, Peter J; Dyer, Michael A; Golub, Todd R; Stegmaier, Kimberly; Hahn, William C; Stewart, Elizabeth A; Schreiber, Stuart L; Roberts, Charles W M.
Afiliação
  • Oberlick EM; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Rees MG; Broad Institute, Cambridge, MA 02142, USA. Electronic address: reesm@broadinstitute.org.
  • Seashore-Ludlow B; Broad Institute, Cambridge, MA 02142, USA; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
  • Vazquez F; Broad Institute, Cambridge, MA 02142, USA.
  • Nelson GM; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
  • Dharia NV; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA; Boston Children's Hospital, Boston, MA 02115, USA.
  • Weir BA; Broad Institute, Cambridge, MA 02142, USA.
  • Tsherniak A; Broad Institute, Cambridge, MA 02142, USA.
  • Ghandi M; Broad Institute, Cambridge, MA 02142, USA.
  • Krill-Burger JM; Broad Institute, Cambridge, MA 02142, USA.
  • Meyers RM; Broad Institute, Cambridge, MA 02142, USA.
  • Wang X; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Montgomery P; Broad Institute, Cambridge, MA 02142, USA.
  • Root DE; Broad Institute, Cambridge, MA 02142, USA.
  • Bieber JM; Broad Institute, Cambridge, MA 02142, USA.
  • Radko S; Comprehensive Cancer Center and Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Cheah JH; Broad Institute, Cambridge, MA 02142, USA.
  • Hon CS; Broad Institute, Cambridge, MA 02142, USA.
  • Shamji AF; Broad Institute, Cambridge, MA 02142, USA.
  • Clemons PA; Broad Institute, Cambridge, MA 02142, USA.
  • Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Harvard Ludwig Center, Harvard Medical School, Boston, MA 02115, USA.
  • Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Golub TR; Broad Institute, Cambridge, MA 02142, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA; Boston Children's Hospital, Boston, MA 02115, USA.
  • Hahn WC; Broad Institute, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Stewart EA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Schreiber SL; Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  • Roberts CWM; Comprehensive Cancer Center and Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: charles.roberts@stjude.org.
Cell Rep ; 28(9): 2331-2344.e8, 2019 08 27.
Article em En | MEDLINE | ID: mdl-31461650
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tumor Rabdoide / Inibidores de Proteínas Quinases / Proteína Tirosina Fosfatase não Receptora Tipo 11 / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Tumor Rabdoide / Inibidores de Proteínas Quinases / Proteína Tirosina Fosfatase não Receptora Tipo 11 / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos