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Bioinspired Peptoid Nanotubes for Targeted Tumor Cell Imaging and Chemo-Photodynamic Therapy.
Luo, Yanan; Song, Yang; Wang, Mingming; Jian, Tengyue; Ding, Shichao; Mu, Peng; Liao, Zhihao; Shi, Qiurong; Cai, Xiaoli; Jin, Haibao; Du, Dan; Dong, Wen-Ji; Chen, Chun-Long; Lin, Yuehe.
Afiliação
  • Luo Y; School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
  • Song Y; School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
  • Wang M; Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
  • Jian T; Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
  • Ding S; School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
  • Mu P; Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
  • Liao Z; Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
  • Shi Q; School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
  • Cai X; School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
  • Jin H; Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
  • Du D; School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
  • Dong WJ; Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, 99164, USA.
  • Chen CL; Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
  • Lin Y; Department of Chemical Engineering, University of Washington, Washington, 98195, USA.
Small ; 15(43): e1902485, 2019 10.
Article em En | MEDLINE | ID: mdl-31468663
ABSTRACT
Substantial progress has been made in applying nanotubes in biomedical applications such as bioimaging and drug delivery due to their unique architecture, characterized by very large internal surface areas and high aspect ratios. However, the biomedical applications of organic nanotubes, especially for those assembled from sequence-defined molecules, are very uncommon. In this paper, the synthesis of two new peptoid nanotubes (PepTs1 and PepTs2) is reported by using sequence-defined and ligand-tagged peptoids as building blocks. These nanotubes are highly robust due to sharing a similar structure to those of nontagged ones, and offer great potential to hold guest molecules for biomedical applications. The findings indicate that peptoid nanotubes loaded with doxorubicin drugs are promising candidates for targeted tumor cell imaging and chemo-photodynamic therapy.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fotoquimioterapia / Peptoides / Biomimética / Nanotubos / Neoplasias Limite: Humans Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fotoquimioterapia / Peptoides / Biomimética / Nanotubos / Neoplasias Limite: Humans Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos