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Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System.
Zhu, Yunlu; Crowley, Samantha C; Latimer, Andrew J; Lewis, Gwendolyn M; Nash, Rebecca; Kucenas, Sarah.
Afiliação
  • Zhu Y; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
  • Crowley SC; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
  • Latimer AJ; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
  • Lewis GM; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
  • Nash R; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.
  • Kucenas S; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA. Electronic address: sk4ub@virginia.edu.
Cell ; 179(1): 74-89.e10, 2019 09 19.
Article em En | MEDLINE | ID: mdl-31495570
During neural tube closure and spinal cord development, many cells die in both the central and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived professional phagocytes have not yet colonized the trunk region during early neurogenesis. How apoptotic cells are removed from this region during these stages remains largely unknown. Using live imaging in zebrafish, we demonstrate that neural crest cells (NCCs) respond rapidly to dying cells and phagocytose cellular debris around the neural tube. Additionally, NCCs have the ability to enter the CNS through motor exit point transition zones and clear debris in the spinal cord. Surprisingly, NCCs phagocytosis mechanistically resembles macrophage phagocytosis and their recruitment toward cellular debris is mediated by interleukin-1ß. Taken together, our results reveal a role for NCCs in phagocytosis of debris in the developing nervous system before the presence of professional phagocytes.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fagocitose / Medula Espinal / Movimento Celular / Sistema Nervoso Periférico / Neurogênese / Crista Neural Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fagocitose / Medula Espinal / Movimento Celular / Sistema Nervoso Periférico / Neurogênese / Crista Neural Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos