A human-like bile acid pool induced by deletion of hepatic <i>Cyp2c70</i> modulates effects of FXR activation in mice.

de Boer, Jan Freark; Verkade, Esther; Mulder, Niels L; de Vries, Hilde D; Huijkman, Nicolette; Koehorst, Martijn; Boer, Theo; Wolters, Justina C; Bloks, Vincent W; van de Sluis, Bart; Kuipers, Folkert

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice.

de Boer, Jan Freark; Verkade, Esther; Mulder, Niels L; de Vries, Hilde D; Huijkman, Nicolette; Koehorst, Martijn; Boer, Theo; Wolters, Justina C; Bloks, Vincent W; van de Sluis, Bart; Kuipers, Folkert.

Afiliação

de Boer JF; Departments of Laboratory Medicine University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Verkade E; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Mulder NL; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
de Vries HD; Departments of Laboratory Medicine University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; iPSC/CRISPR Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Huijkman N; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; University of Groningen, Campus Fryslân, Leeuwarden, The Netherlands.
Koehorst M; Departments of Laboratory Medicine University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Boer T; Departments of Laboratory Medicine University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Wolters JC; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bloks VW; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
van de Sluis B; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; University of Groningen, Campus Fryslân, Leeuwarden, The Netherlands.
Kuipers F; Departments of Laboratory Medicine University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

J Lipid Res ; 61(3): 291-305, 2020 03.

Article em En | MEDLINE | ID: mdl-31506275

Assuntos

Ácidos e Sais Biliares/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Fígado/metabolismo; Receptores Citoplasmáticos e Nucleares/metabolismo; Animais; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos

Palavras-chave

cholesterol; cytochrome P450 family 2 subfamily c polypeptide 70; humanized mouse model; liver; transintestinal cholesterol excretion

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ácidos e Sais Biliares / Receptores Citoplasmáticos e Nucleares / Sistema Enzimático do Citocromo P-450 / Fígado Limite: Animals Idioma: En Revista: J Lipid Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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