Can atherosclerosis be cured?
Curr Opin Lipidol
; 30(6): 477-484, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31592794
ABSTRACT
PURPOSE OF REVIEW Determine if evidence supports interventions to prevent development of atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) events and death. RECENT FINDINGS:
An extensive body of evidence supports the fundamental causal role of apolipoprotein B lipoproteins in the development of atherosclerosis. Recent epidemiologic studies have shown that LDL-cholesterol (LDL-C) and non-HDL-cholesterol levels in early adults are associated with accelerated subclinical atherosclerosis and an excess of atherosclerotic cardiovascular events later in life. Animal and human data have shown that intensive LDL-C lowering can regress earlier stages of atherosclerosis.SUMMARY:
The next research priority is evaluating the impact of lowering LDL-C earlier in life to regress early atherosclerosis, followed by trials to demonstrate this approach will eradicate later-life ASCVD events and death. This approach of curing atherosclerosis will likely be the most effective strategy for reducing the huge global burden of atherosclerosis.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Apolipoproteínas B
/
Aterosclerose
/
Lipoproteínas HDL
/
LDL-Colesterol
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Lipidol
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Israel