Splicing regulator SRSF1-3 that controls somatic hypermutation of IgV genes interacts with topoisomerase 1 and AID.

Kumar Singh, Amit; Tamrakar, Anubhav; Jaiswal, Ankit; Kanayama, Naoki; Agarwal, Anshu; Tripathi, Prabhanshu; Kodgire, Prashant

Kumar Singh, Amit; Tamrakar, Anubhav; Jaiswal, Ankit; Kanayama, Naoki; Agarwal, Anshu; Tripathi, Prabhanshu; Kodgire, Prashant.

Afiliação

Kumar Singh A; Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, 453 552, Madhya Pradesh, India.
Tamrakar A; Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, 453 552, Madhya Pradesh, India.
Jaiswal A; Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, 453 552, Madhya Pradesh, India.
Kanayama N; Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan.
Agarwal A; Translational Health Science, and Technological Institute, NCR Biotech Science Cluster, 3rd Milestone Gurugram-Faridabad Expressway, Faridabad, Haryana 121001, India.
Tripathi P; Translational Health Science, and Technological Institute, NCR Biotech Science Cluster, 3rd Milestone Gurugram-Faridabad Expressway, Faridabad, Haryana 121001, India.
Kodgire P; Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, 453 552, Madhya Pradesh, India. Electronic address: pkodgire@iiti.ac.in.

Mol Immunol ; 116: 63-72, 2019 12.

Article em En | MEDLINE | ID: mdl-31622795

Assuntos

Citidina Desaminase/genética; DNA Topoisomerases Tipo I/genética; Genes de Imunoglobulinas/genética; Splicing de RNA/genética; Fatores de Processamento de Serina-Arginina/genética; Hipermutação Somática de Imunoglobulina/genética; Sequência de Aminoácidos; Animais; Linfócitos B/imunologia; Linhagem Celular; Núcleo Celular/genética; Galinhas/genética; Switching de Imunoglobulina; Imunoprecipitação/métodos; Camundongos; Isoformas de Proteínas/genética

Palavras-chave

(AID); Activation-induced cytidine deaminase; Immunoglobulin (Ig) genes; Somatic hypermutation (SHM); Splicing regulator SRSF1-3; Topoisomerase 1 (TOP1)

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Genes de Imunoglobulinas / Splicing de RNA / DNA Topoisomerases Tipo I / Citidina Desaminase / Hipermutação Somática de Imunoglobulina / Fatores de Processamento de Serina-Arginina Limite: Animals Idioma: En Revista: Mol Immunol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia

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