Comparative study on metabolic profiling and excretion in rat bile between combination of notoginseng total saponins and safflower total flavonoids and its individual extracts by LC-MS/MS.

Song, Jin-Yang; Chen, Jin-Feng; Lu, Ying-Yuan; Chang, Kun; Zhao, Ming-Bo; Tu, Peng-Fei; Jiang, Yong; Guo, Xiao-Yu

Song, Jin-Yang; Chen, Jin-Feng; Lu, Ying-Yuan; Chang, Kun; Zhao, Ming-Bo; Tu, Peng-Fei; Jiang, Yong; Guo, Xiao-Yu.

Afiliação

Song JY; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
Chen JF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
Lu YY; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
Chang K; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
Zhao MB; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
Tu PF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China.
Jiang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China. Electronic address: yongjiang@bjmu.edu.cn.
Guo XY; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China. Electronic address: guoxiaoyu@bjmu.edu.cn.

J Pharm Biomed Anal ; 178: 112936, 2020 Jan 30.

Article em En | MEDLINE | ID: mdl-31672581

Assuntos

Bile/metabolismo; Carthamus tinctorius/química; Flavonoides/química; Panax notoginseng/química; Saponinas/química; Animais; Cromatografia Líquida de Alta Pressão/métodos; Medicamentos de Ervas Chinesas/química; Ginsenosídeos/química; Masculino; Metaboloma; Ratos; Ratos Sprague-Dawley; Sensibilidade e Especificidade; Espectrometria de Massas em Tandem/métodos

Palavras-chave

Bile excretion; Metabolic profiling; Notoginseng total saponins (NS); Safflower total flavonoids (SF); Synergistic action

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Saponinas / Bile / Flavonoides / Carthamus tinctorius / Panax notoginseng Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2020 Tipo de documento: Article

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