Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors.

Onyszkiewicz, Maksymilian; Gawrys-Kopczynska, Marta; Konopelski, Piotr; Aleksandrowicz, Marta; Sawicka, Aneta; Kozniewska, Ewa; Samborowska, Emilia; Ufnal, Marcin

Onyszkiewicz, Maksymilian; Gawrys-Kopczynska, Marta; Konopelski, Piotr; Aleksandrowicz, Marta; Sawicka, Aneta; Kozniewska, Ewa; Samborowska, Emilia; Ufnal, Marcin.

Afiliação

Onyszkiewicz M; Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Gawrys-Kopczynska M; Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Konopelski P; Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Aleksandrowicz M; Department of Neurosurgery, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Sawicka A; Department of Neurosurgery, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Kozniewska E; Department of Neurosurgery, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Samborowska E; Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Ufnal M; Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland. mufnal@wum.edu.pl.

Pflugers Arch ; 471(11-12): 1441-1453, 2019 12.

Article em En | MEDLINE | ID: mdl-31728701

Assuntos

Pressão Arterial/efeitos dos fármacos; Ácido Butírico/farmacologia; Colo/efeitos dos fármacos; Microbioma Gastrointestinal/fisiologia; Receptores Acoplados a Proteínas G/metabolismo; Nervo Vago/efeitos dos fármacos; Animais; Artérias/efeitos dos fármacos; Artérias/metabolismo; Colo/metabolismo; Ácidos Graxos Voláteis/farmacologia; Frequência Cardíaca/efeitos dos fármacos; Hipotensão/tratamento farmacológico; Hipotensão/metabolismo; Masculino; NG-Nitroarginina Metil Éster/farmacologia; Ratos; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos; Nervo Vago/metabolismo

Palavras-chave

Bacterial metabolites; Blood pressure; Butyric acid; SCFA

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Nervo Vago / Colo / Ácido Butírico / Receptores Acoplados a Proteínas G / Pressão Arterial / Microbioma Gastrointestinal Limite: Animals Idioma: En Revista: Pflugers Arch Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Polônia

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