Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes.

Claessens, Laura A; Wesselius, Joris; van Lummel, Menno; Laban, Sandra; Mulder, Flip; Mul, Dick; Nikolic, Tanja; Aanstoot, Henk-Jan; Koeleman, Bobby P C; Roep, Bart O

Claessens, Laura A; Wesselius, Joris; van Lummel, Menno; Laban, Sandra; Mulder, Flip; Mul, Dick; Nikolic, Tanja; Aanstoot, Henk-Jan; Koeleman, Bobby P C; Roep, Bart O.

Afiliação

Claessens LA; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Wesselius J; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
van Lummel M; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Laban S; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Mulder F; Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Mul D; Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, the Netherlands.
Nikolic T; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Aanstoot HJ; Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, the Netherlands.
Koeleman BPC; Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Roep BO; Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. broep@coh.org.

Diabetologia ; 63(2): 351-361, 2020 02.

Article em En | MEDLINE | ID: mdl-31754749

Assuntos

Autoimunidade/fisiologia; Diabetes Mellitus Tipo 1/imunologia; Diabetes Mellitus Tipo 1/metabolismo; Adolescente; Adulto; Autoimunidade/genética; Proliferação de Células/genética; Proliferação de Células/fisiologia; Criança; Pré-Escolar; Estudos Transversais; Diabetes Mellitus Tipo 1/genética; Feminino; Genótipo; Antígenos HLA-DQ/metabolismo; Antígenos HLA-DR/metabolismo; Humanos; Insulina/metabolismo; Masculino; Análise de Componente Principal; Precursores de Proteínas/metabolismo; Estudos Retrospectivos; Linfócitos T/metabolismo; Adulto Jovem

Palavras-chave

Autoimmune disease; Autoreactive T cells; Disease endotypes; Disease heterogeneity; Epitope spreading; Immunotherapy; Islet autoantigen; Patient heterogeneity; Personalised medicine; Precision medicine

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Autoimunidade / Diabetes Mellitus Tipo 1 Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Diabetologia Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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