Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma.
Br J Cancer
; 122(3): 413-420, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31761900
ABSTRACT
BACKGROUND:
Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC).METHODS:
The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TIICs, and PD-L1 expression on tumour cells (PD-L1TC) were immunohistochemically examined in the surface (Surf), centre (Cent) and invasive front (Inv) of tumours surgically resected from 192 patients with ESCC.RESULTS:
The PD-L1+ rate was lower in Inv than in Cent (12.0% vs. 18.2%, P = 0.012), although the numbers of CD8+ TIICs and PD-1+ TIICs were comparable among intratumoural locations. High numbers of CD8+ and PD-1+ TIICs and positive PD-L1TC were related to better overall survival (OS) only in Surf and Cent (CD8 P = 0.012 in Surf, 0.018 in Cent, and 0.165 in Inv; PD-1 P = 0.028 in Surf, 0.021 in Cent, and 0.208 in Inv; and PD-L1 0.044 in Surf, 0.026 in Cent, and 0.718 in Inv). Positive PD-L1TC in Surf and/or Cent but not in Inv demonstrated a strong tendency toward better OS (P = 0.053).CONCLUSIONS:
Immune microenvironments according to the intratumoural location have different effects on the survival of patients with ESCC.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
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Linfócitos do Interstício Tumoral
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Microambiente Tumoral
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Carcinoma de Células Escamosas do Esôfago
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão