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Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects.
Danto, Spencer I; Shojaee, Negin; Singh, Ravi Shankar P; Li, Cheryl; Gilbert, Steven A; Manukyan, Zorayr; Kilty, Iain.
Afiliação
  • Danto SI; Immunology and Inflammation Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA. spencer.i.danto@pfizer.com.
  • Shojaee N; Immunology and Inflammation Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.
  • Singh RSP; Immunology and Inflammation Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.
  • Li C; Immunology and Inflammation Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.
  • Gilbert SA; Immunology and Inflammation Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.
  • Manukyan Z; Immunology and Inflammation Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.
  • Kilty I; Immunology and Inflammation Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, 02139, USA.
Arthritis Res Ther ; 21(1): 269, 2019 12 05.
Article em En | MEDLINE | ID: mdl-31805989
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Antirreumáticos / Quinases Associadas a Receptores de Interleucina-1 / Isoquinolinas Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Res Ther Assunto da revista: REUMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Antirreumáticos / Quinases Associadas a Receptores de Interleucina-1 / Isoquinolinas Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Res Ther Assunto da revista: REUMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos