S-15 in combination of Akt inhibitor promotes the expansion of CD45RA-CCR7+ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1+Tim-3+ cells as well as regulatory T cells.

Xu, Benling; Yuan, Long; Chen, Guangyu; Li, Tiepeng; Zhou, Jinxue; Zhang, Chengjuan; Qin, Peng; Muthana, Musleh M; Wang, Shengdian; Du, Xuexiang; Gao, Quanli

S-15 in combination of Akt inhibitor promotes the expansion of CD45RA^-CCR7⁺ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1⁺Tim-3⁺ cells as well as regulatory T cells.

Xu, Benling; Yuan, Long; Chen, Guangyu; Li, Tiepeng; Zhou, Jinxue; Zhang, Chengjuan; Qin, Peng; Muthana, Musleh M; Wang, Shengdian; Du, Xuexiang; Gao, Quanli.

Afiliação

Xu B; 1Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Yuan L; 2Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Chen G; 1Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Li T; 1Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Zhou J; 3Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Zhang C; 1Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Qin P; 1Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Muthana MM; 4Division of Immunotherapy, Institute of Human Virology, University of Maryland, Baltimore, MD 21201 USA.
Wang S; 5CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Du X; 1Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.
Gao Q; 1Department of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan People's Republic of China.

Cancer Cell Int ; 19: 322, 2019.

Article em En | MEDLINE | ID: mdl-31827396

Palavras-chave

Akt inhibitor; Central memory T cells; Hepatocellular cancer; Programmed death 1; Regulatory T-cells; Tumor infiltrating T lymphocytes

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Cancer Cell Int Ano de publicação: 2019 Tipo de documento: Article