Normative data for multiple breath washout outcomes in school-aged Caucasian children.
Eur Respir J
; 55(4)2020 04.
Article
em En
| MEDLINE
| ID: mdl-31862765
ABSTRACT
BACKGROUND:
The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. The aim of this study was to generate reference values for N2MBW outcomes in a cohort of healthy Caucasian school-aged children.METHODS:
N2MBW data from healthy Caucasian school-age children between 6 and 18â years old were collected from four experienced centres. Measurements were performed using an ultrasonic flowmeter (Exhalyzer D, Eco Medics AG, Duernten, Switzerland) and were analysed with commercial software (Spiroware version 3.2.1, Eco Medics AG). Normative values and upper limits of normal (ULN) were generated for lung clearance index (LCI) at 2.5% (LCI2.5%) and at 5% (LCI5%) of the initial nitrogen concentration and for moment ratios (M1/M0 and M2/M0). A prediction equation was generated for functional residual capacity (FRC).RESULTS:
Analysis used 485 trials from 180 healthy Caucasian children aged from 6 to 18â years old. While LCI increased with age, this increase was negligible (0.04â units·year-1 for LCI2.5%) and therefore fixed ULN were defined for this age group. These limits were 7.91 for LCI2.5%, 5.73 for LCI5%, 1.75 for M1/M0 and 6.15 for M2/M0, respectively. Height and weight were found to be independent predictors of FRC.CONCLUSION:
We report reference values for N2MBW outcomes measured on a commercially available ultrasonic flowmeter device (Exhalyzer D, Eco Medics AG) in healthy school-aged children to allow accurate interpretation of ventilation distribution outcomes and FRC in children with lung disease.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Instituições Acadêmicas
/
Pulmão
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Child
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Eur Respir J
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suíça