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SND1 facilitates the invasion and migration of cervical cancer cells by Smurf1-mediated degradation of FOXA2.
Zhan, Fuliang; Zhong, Yanying; Qin, Yunna; Li, Liang; Wu, Wenwen; Yao, Meizhen.
Afiliação
  • Zhan F; Department of gynaecology and obstetrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.
  • Zhong Y; Department of gynaecology and obstetrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.
  • Qin Y; Department of Pathology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.
  • Li L; Department of obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, 330006, China.
  • Wu W; Department of gynaecology and obstetrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.
  • Yao M; Department of gynaecology and obstetrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China. Electronic address: yaomeizhen076@sina.com.
Exp Cell Res ; 388(1): 111809, 2020 03 01.
Article em En | MEDLINE | ID: mdl-31891682
Staphylococcal nuclease domain-containing protein 1 (SND1) is known to be involved in the progression of a variety of human cancers. However, the role of SND1 in cervical cancer remains unclear. Here, we found that the expression of SND1 in cervical cancer tissue was higher than that in normal cervical tissue. Importantly, high SND1 expression was closely associated with tumorigenic phenotype and shorter survival among cervical cancer patients. Functional assays demonstrated that SND1 knockdown inhibited the migration and invasion capabilities of cervical cancer cells in vitro. Additionally, a xenograft assay showed that silencing SND1 in cervical cancer cells suppressed lung metastasis in vivo. Further investigation revealed that knockdown of SND1 inhibited epithelial-to-mesenchymal transition (EMT) of cervical cancer cells by enhancing FOXA2 expression. Moreover, the pro-metastasis effect of SND1 in cervical cancer was at least in part dependent on FOXA2 inhibition. Mechanistically, we found that SND1-induced FOXA2 ubiquitination resulted in degradation, mediated by the E3 ligase enzyme Smurf1. In summary, SND1 plays a crucial role in cervical cancer metastasis, and we provide evidence that SND1 may serve as a prognostic and therapeutic target in cervical cancer.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Movimento Celular / Neoplasias do Colo do Útero / Ubiquitina-Proteína Ligases / Endonucleases / Fator 3-beta Nuclear de Hepatócito Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Middle aged Idioma: En Revista: Exp Cell Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Movimento Celular / Neoplasias do Colo do Útero / Ubiquitina-Proteína Ligases / Endonucleases / Fator 3-beta Nuclear de Hepatócito Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Middle aged Idioma: En Revista: Exp Cell Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China