HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic ß-cells in vitro by activation of Smoothened.

Yalcinkaya, Mustafa; Kerksiek, Anja; Gebert, Katrin; Annema, Wijtske; Sibler, Rahel; Radosavljevic, Silvija; Lütjohann, Dieter; Rohrer, Lucia; von Eckardstein, Arnold

Yalcinkaya, Mustafa; Kerksiek, Anja; Gebert, Katrin; Annema, Wijtske; Sibler, Rahel; Radosavljevic, Silvija; Lütjohann, Dieter; Rohrer, Lucia; von Eckardstein, Arnold.

Afiliação

Yalcinkaya M; Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland.
Kerksiek A; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Gebert K; Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland.
Annema W; Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland.
Sibler R; Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland.
Radosavljevic S; Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland.
Lütjohann D; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Rohrer L; Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland.
von Eckardstein A; Institute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland arnold.voneckardstein@usz.ch.

J Lipid Res ; 61(4): 492-504, 2020 04.

Article em En | MEDLINE | ID: mdl-31907205

Assuntos

Apoptose/efeitos dos fármacos; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Células Secretoras de Insulina/citologia; Células Secretoras de Insulina/efeitos dos fármacos; Lipoproteínas HDL/farmacologia; Receptor Smoothened/metabolismo; Animais; Linhagem Celular; Colesterol/metabolismo; Proteínas Hedgehog/metabolismo; Homeostase/efeitos dos fármacos; Células Secretoras de Insulina/metabolismo; Ratos; Transdução de Sinais/efeitos dos fármacos; Triglicerídeos/metabolismo

Palavras-chave

adenosine 5'-triphosphate binding cassette transporter; cholesterol efflux; cholesterol metabolism; cytochrome P450 enzyme; hedgehog signaling; high density lipoprotein; lipoprotein receptors; oxysterols

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Apoptose / Células Secretoras de Insulina / Estresse do Retículo Endoplasmático / Receptor Smoothened / Lipoproteínas HDL Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Lipid Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça

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