A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions.

Yin, JieXiang; Stark, Roderick T; Fallis, Ian A; Browne, Duncan L

Yin, JieXiang; Stark, Roderick T; Fallis, Ian A; Browne, Duncan L.

Afiliação

Yin J; School of Chemistry , Cardiff University , Main Building, Park Place , Cardiff CF10 3AT , U.K.
Stark RT; School of Chemistry , Cardiff University , Main Building, Park Place , Cardiff CF10 3AT , U.K.
Fallis IA; School of Chemistry , Cardiff University , Main Building, Park Place , Cardiff CF10 3AT , U.K.
Browne DL; School of Chemistry , Cardiff University , Main Building, Park Place , Cardiff CF10 3AT , U.K.

J Org Chem ; 85(4): 2347-2354, 2020 02 21.

Article em En | MEDLINE | ID: mdl-31913623

ABSTRACT

ABSTRACT

A ball-milling-enabled zinc-mediated Barbier-type allylation reaction is reported. Notably, running the reaction in this manner renders it effective irrespective of the initial morphology of the zinc metal. The process is operationally simple, does not require inert atmospheres or dry solvents, and is reported over a range of aldehyde and ketone substrates; a gram-scale process is demonstrated.

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido