SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.

Lee, Da Hyun; Park, Jeong Su; Lee, Yu Seol; Han, Jisu; Lee, Dong-Kyu; Kwon, Sung Won; Han, Dai Hoon; Lee, Yong-Ho; Bae, Soo Han

Lee, Da Hyun; Park, Jeong Su; Lee, Yu Seol; Han, Jisu; Lee, Dong-Kyu; Kwon, Sung Won; Han, Dai Hoon; Lee, Yong-Ho; Bae, Soo Han.

Afiliação

Lee DH; Severance Biomedical Science Institute, Yonsei University College of Medicine , Seoul, Republic of Korea.
Park JS; Brain Korea 21 PLUS Project for Medical Science, Yonsei University , Seoul, South Korea.
Lee YS; Severance Biomedical Science Institute, Yonsei University College of Medicine , Seoul, Republic of Korea.
Han J; Severance Biomedical Science Institute, Yonsei University College of Medicine , Seoul, Republic of Korea.
Lee DK; Brain Korea 21 PLUS Project for Medical Science, Yonsei University , Seoul, South Korea.
Kwon SW; Severance Biomedical Science Institute, Yonsei University College of Medicine , Seoul, Republic of Korea.
Han DH; Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul, Republic of Korea.
Lee YH; Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul, Republic of Korea.
Bae SH; College of Pharmacy, Seoul National University , Seoul, Republic of Korea.

Autophagy ; 16(11): 1949-1973, 2020 11.

Article em En | MEDLINE | ID: mdl-31913745

Assuntos

Autofagia/fisiologia; Ácidos Graxos/toxicidade; Hepatócitos/efeitos dos fármacos; Fígado/efeitos dos fármacos; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Autofagia/genética; Fibroblastos/metabolismo; Hepatócitos/metabolismo; Humanos; Proteína 1 Associada a ECH Semelhante a Kelch/efeitos dos fármacos; Camundongos Knockout; Fator 2 Relacionado a NF-E2/efeitos dos fármacos; Espécies Reativas de Oxigênio/metabolismo; Proteína Sequestossoma-1/efeitos dos fármacos

Palavras-chave

KEAP1-NFE2L2 pathway; NAFLD; SQSTM1; ULK1; lipotoxicity

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Autofagia / Hepatócitos / Ácidos Graxos / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Autophagy Ano de publicação: 2020 Tipo de documento: Article

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