CRISPR/Cas9 gene editing demonstrates metabolic importance of GPR55 in the modulation of GIP release and pancreatic beta cell function.

McCloskey, A G; Miskelly, M G; Moore, C B T; Nesbit, M A; Christie, K A; Owolabi, A I; Flatt, P R; McKillop, A M

McCloskey, A G; Miskelly, M G; Moore, C B T; Nesbit, M A; Christie, K A; Owolabi, A I; Flatt, P R; McKillop, A M.

Afiliação

McCloskey AG; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland.
Miskelly MG; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland.
Moore CBT; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland.
Nesbit MA; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland.
Christie KA; Center for Genomic Medicine, Massachusetts General Hospital & Harvard Medical School, 185 Cambridge St. Boston, MA 02115, USA.
Owolabi AI; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland.
Flatt PR; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland.
McKillop AM; School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland. Electronic address: am.mckillop@ulster.ac.uk.

Peptides ; 125: 170251, 2020 03.

Article em En | MEDLINE | ID: mdl-31923454

Assuntos

Diabetes Mellitus Experimental/metabolismo; Polipeptídeo Inibidor Gástrico/metabolismo; Edição de Genes/métodos; Peptídeo 1 Semelhante ao Glucagon/metabolismo; Células Secretoras de Insulina/metabolismo; Receptores de Canabinoides/metabolismo; Animais; Sistemas CRISPR-Cas; Linhagem Celular; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/fisiopatologia; Modelos Animais de Doenças; Humanos; Masculino; Camundongos; Receptores de Canabinoides/química; Receptores de Canabinoides/genética

Palavras-chave

CRISPR/Cas9; Cannabinoid; GIP; GLP-1; GPR55; Insulin

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Polipeptídeo Inibidor Gástrico / Receptores de Canabinoides / Diabetes Mellitus Experimental / Células Secretoras de Insulina / Peptídeo 1 Semelhante ao Glucagon / Edição de Genes Limite: Animals / Humans / Male Idioma: En Revista: Peptides Ano de publicação: 2020 Tipo de documento: Article

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