Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.
Annu Rev Biochem
; 89: 235-253, 2020 06 20.
Article
em En
| MEDLINE
| ID: mdl-31928411
ABSTRACT
Predicting regulatory potential from primary DNA sequences or transcription factor binding patterns is not possible. However, the annotation of the genome by chromatin proteins, histone modifications, and differential compaction is largely sufficient to reveal the locations of genes and their differential activity states. The Polycomb Group (PcG) and Trithorax Group (TrxG) proteins are the central players in this cell type-specific chromatin organization. PcG function was originally viewed as being solely repressive and irreversible, as observed at the homeotic loci in flies and mammals. However, it is now clear that modular and reversible PcG function is essential at most developmental genes. Focusing mainly on recent advances, we review evidence for how PcG and TrxG patterns change dynamically during cell type transitions. The ability to implement cell type-specific transcriptional programming with exquisite fidelity is essential for normal development.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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Proteínas Cromossômicas não Histona
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Histonas
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Regulação da Expressão Gênica no Desenvolvimento
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Proteínas de Drosophila
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Drosophila melanogaster
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Proteínas do Grupo Polycomb
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2020
Tipo de documento:
Article