Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents.

Awad, Doaa; Bartok, Melinda; Mostaghimi, Farzin; Schrader, Imke; Sudumbrekar, Neeti; Schaffran, Tanja; Jenne, Carsten; Eriksson, Jonny; Winterhalter, Mathias; Fritz, Jürgen; Edwards, Katarina; Gabel, Detlef

Awad, Doaa; Bartok, Melinda; Mostaghimi, Farzin; Schrader, Imke; Sudumbrekar, Neeti; Schaffran, Tanja; Jenne, Carsten; Eriksson, Jonny; Winterhalter, Mathias; Fritz, Jürgen; Edwards, Katarina; Gabel, Detlef.

Afiliação

Awad D; Department of Biochemistry, Faculty of Science, Alexandria University, Moharam Bek, 21511 Alexandria (Egypt).
Bartok M; Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
Mostaghimi F; Jacobs University Bremen, Campus Ring 1, 28759 Bremen (Germany).
Schrader I; Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
Sudumbrekar N; Jacobs University Bremen, Campus Ring 1, 28759 Bremen (Germany).
Schaffran T; Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
Jenne C; Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
Eriksson J; Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
Winterhalter M; Department of Chemistry, University of Bremen, PO Box 330440, 28334 Bremen (Germany).
Fritz J; Fachbereich C-Anorganische Chemie, Bergische Universität Wuppertal, 42119 Wuppertal (Germany).
Edwards K; Department of Chemistry-BMC, Uppsala University, Box 579, 75123 Uppsala (Sweden).
Gabel D; Jacobs University Bremen, Campus Ring 1, 28759 Bremen (Germany).

Chempluschem ; 80(4): 656-664, 2015 Apr.

Article em En | MEDLINE | ID: mdl-31973437

ABSTRACT

ABSTRACT

Halogenated dodecaborates, and especially dodecaiodododecaborate(2-), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo-transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.

Palavras-chave

boron; cluster compounds; cryo-transmission electron microscopy; differential scanning calorimetry; liposomes; triggered release

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