Small molecule biomarkers for neonatal hypoxic ischemic encephalopathy.
Semin Fetal Neonatal Med
; 25(2): 101084, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31983670
ABSTRACT
Hypoxic Ischemic Encephalopathy (HIE) is one of the most deleterious conditions in the perinatal period and the access to small molecule biomarkers aiding accurate diagnosis and disease staging, progress monitoring, and early outcome prognosis could provide relevant advances towards the development of personalized therapies. The emergence of metabolomics, the "omics" technology enabling the holistic study of small molecules, for biomarker discovery employing different analytical platforms, animal models and study populations has drastically increased the number and diversity of small molecules proposed as candidate biomarkers. However, the use of very few compounds has been implemented in clinical guidelines and authorized medical devices. In this work we review different approaches employed for discovering HIE-related small molecule biomarkers. Their role in associated biochemical disease mechanisms as well as the way towards their translation into the clinical practice are discussed.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Hipóxia-Isquemia Encefálica
/
Doenças do Recém-Nascido
Tipo de estudo:
Etiology_studies
/
Guideline
/
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Semin Fetal Neonatal Med
Assunto da revista:
PEDIATRIA
/
PERINATOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha