Complex Mitochondrial Dysfunction Induced by TPP<sup>+</sup>-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells.

Fuentes-Retamal, Sebastián; Sandoval-Acuña, Cristian; Peredo-Silva, Liliana; Guzmán-Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro-Castillo, Vicente; Catalán, Mabel; Kemmerling, Ulrike; Urra, Félix A; Ferreira, Jorge

Complex Mitochondrial Dysfunction Induced by TPP⁺-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells.

Fuentes-Retamal, Sebastián; Sandoval-Acuña, Cristian; Peredo-Silva, Liliana; Guzmán-Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro-Castillo, Vicente; Catalán, Mabel; Kemmerling, Ulrike; Urra, Félix A; Ferreira, Jorge.

Afiliação

Fuentes-Retamal S; Clinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Sandoval-Acuña C; Institute of Biotechnology, Czech Academy of Sciences, 25250 Prague, Czech Republic.
Peredo-Silva L; School of Pharmacy, Faculty of Medicine, Andrés Bello National University, Santiago 8370149, Chile.
Guzmán-Rivera D; Clinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Pavani M; Clinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Torrealba N; Institute of Biotechnology, Czech Academy of Sciences, 25250 Prague, Czech Republic.
Truksa J; Institute of Biotechnology, Czech Academy of Sciences, 25250 Prague, Czech Republic.
Castro-Castillo V; Department of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile.
Catalán M; Clinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Kemmerling U; Developmental Biology, Program of Anatomy, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Urra FA; Clinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Ferreira J; Clinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile.

Cells ; 9(2)2020 02 11.

Article em En | MEDLINE | ID: mdl-32053908

Assuntos

Antineoplásicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Mitocôndrias/efeitos dos fármacos; Biossíntese de Proteínas/efeitos dos fármacos; Quinases Proteína-Quinases Ativadas por AMP; Apoptose/efeitos dos fármacos; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Proliferação de Células/efeitos dos fármacos; Doxiciclina/farmacologia; Sinergismo Farmacológico; Feminino; Gentisatos/química; Gentisatos/farmacologia; Compostos Heterocíclicos/química; Compostos Heterocíclicos/farmacologia; Humanos; Complexo Cetoglutarato Desidrogenase/antagonistas & inibidores; Complexo Cetoglutarato Desidrogenase/genética; Mitocôndrias/patologia; Compostos Organofosforados/química; Compostos Organofosforados/farmacologia; Fosforilação Oxidativa/efeitos dos fármacos; Proteínas Quinases/genética; Ribossomos/efeitos dos fármacos

Palavras-chave

decyl polyhydroxybenzoate triphenylphosphonium derivatives; doxycycline; inhibition of alpha-ketoglutarate dehydrogenase complex; inhibition of the electron transport chain; mitochondrial ribosome inhibition; mitochondrially targeted

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / Neoplasias da Mama / Mitocôndrias / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Cells Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile

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