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Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity.
Suiter, Chase C; Moriyama, Takaya; Matreyek, Kenneth A; Yang, Wentao; Scaletti, Emma Rose; Nishii, Rina; Yang, Wenjian; Hoshitsuki, Keito; Singh, Minu; Trehan, Amita; Parish, Chris; Smith, Colton; Li, Lie; Bhojwani, Deepa; Yuen, Liz Y P; Li, Chi-Kong; Li, Chak-Ho; Yang, Yung-Li; Walker, Gareth J; Goodhand, James R; Kennedy, Nicholas A; Klussmann, Federico Antillon; Bhatia, Smita; Relling, Mary V; Kato, Motohiro; Hori, Hiroki; Bhatia, Prateek; Ahmad, Tariq; Yeoh, Allen E J; Stenmark, Pål; Fowler, Douglas M; Yang, Jun J.
Afiliação
  • Suiter CC; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Moriyama T; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Matreyek KA; Department of Genome Sciences, University of Washington, Seattle, WA 98195.
  • Yang W; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Scaletti ER; Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, 106 91 Stockholm, Sweden.
  • Nishii R; Department of Experimental Medical Science,Lund University, 221 00 Lund, Sweden.
  • Yang W; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Hoshitsuki K; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Singh M; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Trehan A; Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research, 160012 Chandigarh, India.
  • Parish C; Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research, 160012 Chandigarh, India.
  • Smith C; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Li L; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Bhojwani D; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Yuen LYP; Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, CA 90027.
  • Li CK; Department of Pathology, Hong Kong Children's Hospital, Hong Kong.
  • Li CH; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.
  • Yang YL; Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Hong Kong.
  • Walker GJ; Department of Laboratory Medicine and Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 10617, Taiwan.
  • Goodhand JR; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter EX2 5DW, England.
  • Kennedy NA; IBD Pharmacogenetics Group, University of Exeter, Exeter EX2 5DW, England.
  • Klussmann FA; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter EX2 5DW, England.
  • Bhatia S; IBD Pharmacogenetics Group, University of Exeter, Exeter EX2 5DW, England.
  • Relling MV; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter EX2 5DW, England.
  • Kato M; IBD Pharmacogenetics Group, University of Exeter, Exeter EX2 5DW, England.
  • Hori H; Unidad Nacional de Oncología Pediátrica, Guatemala City 01011, Guatemala.
  • Bhatia P; Department of Pediatrics, Francisco Marroquin Medical School, Guatemala City 01011, Guatemala.
  • Ahmad T; Division of Pediatric Hematology/Oncology, Institute for Cancer Outcomes and Survivorship, School of Medicine, University of Alabama, Birmingham, AL 35294.
  • Yeoh AEJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Stenmark P; Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo 157-8535, Japan.
  • Fowler DM; Department of Pediatrics, Mie University Graduate School of Medicine, Mie 514-8507, Japan.
  • Yang JJ; Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research, 160012 Chandigarh, India.
Proc Natl Acad Sci U S A ; 117(10): 5394-5401, 2020 03 10.
Article em En | MEDLINE | ID: mdl-32094176
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pirofosfatases / Variantes Farmacogenômicos / Mercaptopurina / Antimetabólitos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pirofosfatases / Variantes Farmacogenômicos / Mercaptopurina / Antimetabólitos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article